Publications
2023
28.Katkar Gajanan and Ghosh Pradipta. Macrophage states: there's a method in the madness. Trends in Immunology. Nov 2023. https://doi.org/10.1016/j.it.2023.10.006
27. Anandachar MS, Roy S, Sinha S, Boadi A, Katkar GD, Ghosh P. Diverse Gut Pathogens Exploit the Host Engulfment Pathway via a Conserved Mechanism. J Biol Chem. 2023 Oct 25:105390. doi: 10.1016/j.jbc.2023.105390. PMID: 37890785
26. Tindle C, Katkar GD, Fonseca AG, Taheri S, Lee J, Maity P, Sayed IM, Ibeawuchi SR, Vidales E, Pranadinata RF, Fuller M, Stec DL, Anandachar MS, Perry K, Le HN, Ear J, Boland BS, Sandborn WJ, Sahoo D, Das S, Ghosh P. A Living Organoid Biobank of Crohn's Disease Patients Reveals Molecular Subtypes for Personalized Therapeutics..bioRxiv. 2023 Mar 13:2023.03.11.532245. doi: 10.1101/2023.03.11.532245. Preprint.PMID: 36993763
2022
25. Katkar GD, Mahitha Shree Anandachar, Saptarshi Sinha, Stella-Rita Ibeawuchi, Celia R. Espinoza, Jane Coates, Yashaswat S. Malhotra, Madhubanti Mullick, Vanessa Castillo, Daniella T. Vo, Debashis Sahoo, Pradipta Ghosh. Coupling of NOD2 to GIV is Required for Bacterial Sensing. Bio-Rxiv, 2022. doi: https://doi.org/10.1101/2022.04.26.489574 First author (Under review at Cell reports).
24. Saptarshi Sinha, Vanessa Castillo, Celia R. Espinoza, Courtney Tindle, Ayden G. Fonseca, Jen-nifer M. Dan, Gajanan D. Katkar, Soumita Das, Debashis Sahoo, Pradipta Ghosh. COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis. EBioMedicine. 2022 Aug;82:104185. doi: 10.1016/j.ebiom.2022.104185. Epub 2022 Jul 20. PMID: 35870428
23. Katkar, G. D., Sayed, I. M., Anandachar, M. S., Castillo, V., Vidales, E., Toobian, D., Usmani, F., Sawires, J. R., Leriche, G., Yang, J., Sandborn, W. J., Das, S., Sahoo, D., & Ghosh, P. (2022). Artificial intelligence rationalized balanced PPARα/γ dual agonism resets dysregulated macrophage processes in inflammatory bowel disease. Commun Biol, 5(1), 231. doi:10.1038/s42003-022-03168-4. First author
22. Ghosh P#, Katkar GD#, Shimizu C#, Kim J, Khandelwal S, Tremoulet AH, Kanegaye J, Pediatric Emergency Medicine Kawasaki Disease Research Group, Bocchini J, Das S, Burns JC, Sahoo D. (2022) An AI-guided signature reveals the nature of the shared proximal pathways of host immune response in MIS-C and Kawasaki disease. Nat Commun, 13: 2687. Co-first author, equal contribution.
PRESS: Science Daily, EurekAlert,
2021
21. Muntjewerff, E. M., Tang, K., Lutter, L., Christoffersson, G., Nicolasen, M. J. T., Gao, H., Katkar, G. D., Das, S., Ter Beest, M., Ying, W., Ghosh, P., El Aidy, S., Oldenburg, B., van den Bogaart, G., & Mahata, S. K. (2021). Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides. Acta Physiol (Oxf), 232(2), e13655. doi:10.1111/apha.13655
20. Mustafa, M., Abd El-Hafeez, A. A., Abdelhamid, D., Katkar, G. D., Mostafa, Y. A., Ghosh, P., Hayallah, A. M., & Abuo-Rahma, G. E. A. (2021). A first-in-class anticancer dual HDAC2/FAK inhibitors bearing hydroxamates/benzamides capped by pyridinyl-1,2,4-triazoles. Eur J Med Chem, 222, 113569. doi:10.1016/j.ejmech.2021.113569
19. Reynoso, S#., Castillo, V#., Katkar, G. D#., Lopez-Sanchez, I., Taheri, S., Espinoza, C., Rohena, C., Sahoo, D., Gagneux, P., & Ghosh, P. (2021). GIV/Girdin, a non-receptor modulator for Gαi/s, regulates spatiotemporal signaling during sperm capacitation and is required for male fertility. Elife, 10. doi:10.7554/eLife.69160. Co-first author, equal contribution
18. Sahoo, D#., Katkar, G. D#., Khandelwal, S., Behroozikhah, M., Claire, A., Castillo, V., Tindle, C., Fuller, M., Taheri, S., Rogers, T. F., Beutler, N., Ramirez, S. I., Rawlings, S. A., Pretorius, V., Smith, D. M., Burton, D. R., Alexander, L. E. C., Duran, J., Crotty, S., Dan, J. M., Das, S., & Ghosh, P. (2021). AI-guided discovery of the invariant host response to viral pandemics. EBioMedicine, 68, 103390. doi:10.1016/j.ebiom.2021.103390. Co-first author, equal contribution.
INDEPENDENT EDITORIAL: NK cells on the ViP stage of COVID-19. Masselli E, Vitale M.EBioMedicine. 2021 Jul;69:103458. Epub 2021 Jun 26.PMID: 34186492
PRESS: San Diego Tribune; Science Daily; Health IT analytics ; fox5sandiego; Times of San Diego; MLO online; Tech Times; ZENGER news; SciTechDaily; FreePress Journal; IndiatvNews; National Herald India; The Deccan News; Healthcare IT News; medIndia.net; Top 10 news; BigNewsNetwork; ANI news network (South Asia); InnovatorsMag
17. Sahoo, D., Swanson, L., Sayed, I. M., Katkar, G. D., Ibeawuchi, S. R., Mittal, Y., Pranadinata, R. F., Tindle, C., Fuller, M., Stec, D. L., Chang, J. T., Sandborn, W. J., Das, S., & Ghosh, P. (2021). Artificial intelligence guided the discovery of a barrier-protective therapy in inflammatory bowel disease. Nat Commun, 12(1), 4246. doi:10.1038/s41467-021-24470-5
PRESS: GEM news, Science Daily, California News Times, BioTechScope, The-HealthGuide,TheHealthNewsExpress, TittlePress, TheWellnessChecks, Med Lifestyle news, D4-pharma, News-founded (South Africa), News wise, NewsBeezer, MirageNews, FloridaNewsTimes.
16. Tindle, C., Fuller, M., Fonseca, A., Taheri, S., Ibeawuchi, S. R., Beutler, N., Katkar, G. D., Claire, A., Castillo, V., Hernandez, M., Russo, H., Duran, J., Crotty Alexander, L. E., Tipps, A., Lin, G., This-tlethwaite, P. A., Chattopadhyay, R., Rogers, T. F., Sahoo, D., Ghosh, P., & Das, S. (2021). Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19. Elife, 10. doi:10.7554/eLife.66417
2020
15. Sayed, I. M., Suarez, K., Lim, E., Singh, S., Pereira, M., Ibeawuchi, S. R., Katkar, G.D., Dunkel, Y., Mittal, Y., Chattopadhyay, R., Guma, M., Boland, B. S., Dulai, P. S., Sandborn, W. J., Ghosh, P., & Das, S. (2020). Host engulfment pathway controls inflammation in inflammatory bowel disease. FEBS j, 287(18), 3967-3988. doi:10.1111/febs.15236
14. Swanson, L., Katkar, G. D., Tam, J., Pranadinata, R. F., Chareddy, Y., Coates, J., Anandachar, M. S., Castillo, V., Olson, J., Nizet, V., Kufareva, I., Das, S., & Ghosh, P. (2020). TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin. Proc Natl Acad Sci, 117(43), 26895-26906. doi:10.1073/pnas.2011667117
2019
13. Girish, K. S., Katkar, G. D., Harrison, R. A., & Kemparaju, K. (2019). Research into the Causes of Venom-Induced Mortality and Morbidity Identifies New Therapeutic Opportunities. Am J Trop Med Hyg, 100(5), 1043-1048. doi:10.4269/ajtmh.17-0877
12Toobian, D., Ghosh, P., & Katkar, G. D. (2021). Parsing the Role of PPARs in Macrophage Processes. Frontiers in Immunology, 12(5513). doi:10.3389/fimmu.2021.783780. Senior corresponding author.
2018
10. Kemparaju K, Girish KS, Katkar GD. Reply to 'Evidence that neutrophils do not promote Echis carinatus venom-induced tissue destruction. Nat Commun. 2018;9(1):2303.
9. Swethakumar B, NaveenKumar SK, Katkar GD, Girish KS, Kemparaju K. Inhibition of Echis cari-natus venom by DNA, a promising therapeutic molecule for snakebite management. Biochim Biophys Acta. General Subjects 2018;1862(5):1115-1125.
2017
8. Sharma RD, Katkar GD, Sundaram MS, Swethakumar B, Girish KS, Kemparaju K. Melatonin inhibits snake venom and antivenom-induced oxidative stress and augments treatment efficacy. Acta Trop. 2017 May;169:14-25. doi: 10.1016/j.actatropica.2017.01.004. Epub 2017 Jan 12. PMID: 28089603
2016
7. Katkar GD, Sundaram MS, NaveenKumar SK, Swethakumar B, Sharma RD, Paul M, Vishalakshi GJ, Devaraja S, Girish KS, Kemparaju K. NETosis and lack of DNase activity are key factors in Echis carinatus venom-induced tissue destruction. Nat Commun., 2016; 19; 7:11361.
Received notable public attention:
PRESS: Asian scientist, Nature Asia, Discover magazine.
2015
6. Katkar GD, Sharma RD, Vishalakshi GJ, Naveenkumar SK, Madhur G, Thushara RM, Narender T, Girish KS, Kemparaju K. Lupeol derivative mitigates Echis carinatus venom-induced tissue destruction by neutralizing venom toxins and protecting collagen and angiogenic receptors on inflammatory cells. Biochim Biophys Acta. General Subjects 2015;1850(12):2393-409.
5. Sharma RD, Katkar GD, Sundaram MS, Paul M, NaveenKumar SK, Swethakumar B, Hemshekhar M, Girish KS, Kemparaju K. Oxidative stress-induced methemoglobinemia is the silent killer during snakebite: a novel and strategic neutralization by melatonin. J Pineal Res. 2015; 59(2):240-54.
2014
4. Katkar GD, Sundaram MS, Hemshekhar M, Sharma DR, Santhosh MS, Sunitha K, Rangappa KS, Girish KS, Kemparaju K. Melatonin alleviates Echis carinatus venom-induced toxicities by modulating inflammatory mediators and oxidative stress. J Pineal Res., 2014; 56(3):295-312.
2010-2013
3. GD Katkar, O Sridevi, PM Salimath, SP Patil. Combining ability analysis for yield, its contributing characters and fruit quality parameters of exotic Tomato (Lycopersicon esculentum Mill.) breeding lines. Electronic Journal of Plant Breeding 3 (3), 908-915.
2. SL Basavaraju, SB Revanappa, K Prashant, Anand Kanatti, HC Sowmya, KD Gajanan, N Srinivas. Bio-ecology and management of areca nut scale, Parasaissetia nigra (Neitner) and mealybug, Dysmicoccus brevipes (Cockerell). Indian Journal of Agricultural Research 47 (5), 436-440.
1. SB Revanappa, PY Kamannavar, AG Vijaykumar, M Ganajaxi, KD Gajanan, B Arunkumar, PM Salimath. Genotype x environment interaction and stability analysis for grain yield in blackgram (Vigna mungo L.) Legume Research. An International Journal 35 (1), 56-58.